Rand's first major success as a writer came with The Fountainhead in 1943, a romantic and philosophical novel that she wrote over a period of seven years.  The novel centers on an uncompromising young architect named Howard Roark and his struggle against what Rand described as "second-handers"—those who attempt to live through others, placing others above themselves. It was rejected by twelve publishers before finally being accepted by the Bobbs-Merrill Company on the insistence of editor Archibald Ogden, who threatened to quit if his employer did not publish it.  While completing the novel, Rand was prescribed Benzedrine , a brand of amphetamine , to fight fatigue.  The drug helped her to work long hours to meet her deadline for delivering the finished novel, but when the book was done, she was so exhausted that her doctor ordered two weeks' rest.  Her use of the drug for approximately three decades may have contributed to what some of her later associates described as volatile mood swings.